Figure 10.—

The 4-NQO–induced mutagenesis for the catalytic dead rev1 mutant is also lower in Mms2-deficient cells. (A) The 4-NQO–induced mutation frequency of the catalytic dead rev1 strain deviates from the REV1 strain at higher doses of 4-NQO for acute exposure. Strains are YMEW17 (rev1Δmms2Δ pRS416), YMEW18 (rev1Δmms2Δ pRS416-REV1), and YMEW19 (rev1Δmms2Δ pRS416-rev1-catalytic dead). (B) The catalytic dead rev1 mutant is sensitive to acute killing by 4-NQO in the absence of Mms2. The error bars represent one standard deviation of three or more independent cultures.