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. Author manuscript; available in PMC: 2011 Jan 10.
Published in final edited form as: Nat Genet. 2007 Dec 9;40(1):102–107. doi: 10.1038/ng.2007.39

Figure 2.

Figure 2

Immunohistochemical analysis of PTEN and CK5/14 basal-like phenotype markers in 297 non-hereditary human breast carcinomas. (a) Representative PTEN and CK5/14 IHC in two non-hereditary breast tumors. Top, a PTENIHC-positive and CK5/14-negative example; bottom, a PTENIHC-loss and CK5/14-positive example. Arrows indicate tumor cells; arrowheads indicate non-neoplastic cells. Asterix denotes the non-neoplastic CK5/14-positive basal epithelial layer enclosing a portion of in situ breast carcinoma, shown here as an example of an internal positive control. Scale bars, 25 μm. (b) Correlation analysis between PTEN loss and the CK5/14-positive basal-like subtype among all tumors (left) and in the ER-negative group (right). *P = 0.0122; **P = 4 × 10−9.