Table A2.
Bivariate Models of CF, LRF, and TTF Adjusting for Treatment Group
| End Point | HR | 95% CI | P* |
|---|---|---|---|
| CF | |||
| RT duration, days | |||
| ≤ 44 | 1.00 | ||
| > 44 | 1.437 | 1.013 to 2.038 | .0419 |
| Treatment | |||
| RT + FU + mitomycin | 1.00 | ||
| RT + FU + cisplatin | 1.587 | 1.076 to 2.340 | .0199 |
| RT + FU | 1.983 | 1.249 to 3.148 | .0037 |
| LRF | |||
| RT duration continuous + treatment | 1.011 | 1.001 to 1.021 | .0271 |
| RT + FU + mitomycin | 1.00 | ||
| RT + FU + cisplatin | 1.565 | 1.142 to 2.144 | .0053 |
| RT + FU | 2.515 | 1.783 to 3.548 | < .0001 |
| RT duration, days | |||
| ≤ 44 | 1.00 | ||
| > 44 | 1.364 | 1.040 to 1.789 | .0250 |
| RT duration dichotomized + treatment | |||
| RT + FU + mitomycin | 1.00 | ||
| RT + FU + cisplatin | 1.540 | 1.125 to 2.109 | .0071 |
| RT + FU | 2.531 | 1.794 to 3.571 | < .0001 |
| TTF | |||
| RT duration continuous + treatment | 1.010 | 1.001 to 1.019 | .0270 |
| RT + FU + mitomycin | 1.00 | ||
| RT + FU + cisplatin | 1.471 | 1.112 to 1.945 | .0069 |
| RT + FU | 2.044 | 1.490 to 2.803 | < .0001 |
| RT duration, days | |||
| ≤ 44 | 1.00 | ||
| > 44 | 1.302 | 1.020 to 1.663 | .0343 |
| RT duration dichotomized + treatment | |||
| RT + FU + mitomycin | 1.00 | ||
| RT + FU + cisplatin | 1.451 | 1.097 to 1.918 | .0091 |
| RT + FU | 2.048 | 1.494 to 2.809 | < .0001 |
Abbreviations: CF, colostomy failure; LRF, locoregional failure; TTF, time to treatment failure; HR, hazard ratio; RT, radiation therapy; FU, fluorouracil.
*
P value from χ2 test using the Cox proportional hazards model.