Figure 4.

PPARδ is required for efficient tumorigenicity. HCT116, PPARδ +/−, and PPARδ −/− cells were injected as xenografts in nude mice and sacrificed after 34 days as described in Materials and Methods. (A) Representative mice at day 34. (B) Growth curves of HCT116, PPARδ +/−, and PPARδ −/− xenografts. Each data point for HCT116 represents the average tumor size of six mice, and each data point for the PPARδ +/− and PPARδ −/− cell lines represents the average tumor size of five mice. Error bars represent the SEM. Tumors that did not grow were assigned a volume of zero.