Table 1.
3D telomere characteristics of Hodgkin and Reed-Sternberg cells in U-HO1 and U-HO1-PTPN1
| Cell type | Parameter | H-HO1 | H-HO1-PTPN1 | p-value |
|---|---|---|---|---|
| Hodgkin | Total nuclear volume | 4121 ± 1350 μm3 | 3330 ± 844 μm3 | ns |
| Telomeres/cell (n) (Total telomere volume) |
53.8 ± 28.0 | 56.2 ± 19.9 | ns | |
| Telomeres/1000 μm3 of nuclear volume (n) |
14.0 ± 8.4 | 17.2 ± 6.1 | ns | |
| Telomere aggregates/cell (n) | 6.0 ± 4.0 | 6.8 ± 4.2 | ns | |
| Cells with ≥ 20 telomere aggregates (%) |
2.9 | 2.8 | ns | |
| Very short telomeres (< 5000 units; %) |
21.2 | 18.3 | 0.0407 | |
| Reed-Sternberg | Total nuclear volume | 15301 ± 4641 μm3 | 14839 ± 6722 μm3 | ns |
| Telomeres/cell (n) (Total telomere volume) |
123.0 ± 75.3 | 105.7 ± 62.7 | ns | |
| Telomeres/1000 μm3 of nuclear volume (n) |
13.7 ± 30.8 | 7.8 ± 4.0 | ns | |
| Telomere aggregates/cell (n) | 13.8 ± 11.7 | 12.9 ± 10.5 | ns | |
| Cells with ≥ 20 telomere aggregates (%) |
17.2 | 13.8 | ns | |
| Very short telomeres (< 5000 units; %) |
23.4 | 13.8 | < 0.0001 |
ns: p > 0.05