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. 2011 Jan 10;6(1):e14504. doi: 10.1371/journal.pone.0014504

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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This composite graph depicts the mean values and standard deviations (bars) of: A; mean arterial blood pressure and methemoglobin. B; NO metabolome concentrations in plasma (nitrite, nitrate, S-nitrosothiols), red blood cells (C; nitrite and nitrate) and whole blood (D; nitrite and nitrate) in three subjects who did not develop nitrite-related toxicity during sodium nitrite infusion at 266.9 µg/kg/hr [maximal tolerated dose (MTD)] Note that in this group all NO metabolome concentrations returned to baseline levels within 12 hours after completion of sodium nitrite infusion.