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. 2011 Jan 10;6(1):e14504. doi: 10.1371/journal.pone.0014504

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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This composite graph depicts: A; mean arterial blood pressure and methemoglobin and NO metabolome concentrations in plasma (B; nitrite, nitrate, S-nitrosothiols), red blood cells (C; nitrite and nitrate) and whole blood (D; nitrite and nitrate) in subject 11 who developed significant methemoglobinemia during sodium nitrite infusion at 445.7 µg/kg/hr. Mean arterial blood pressure remained stable during the infusion. The infusion remained uneventful until 2 and 5 minutes after the infusion cessation when methemoglobin level increased above 5% (A). However, it decreased during the next 5 minutes and returned to baseline at 8 hours after stopping sodium nitrite infusion. The subject remained asymptomatic. Within the NO metabolome only nitrite concentrations in plasma and red blood cells returned to baseline values; plasma nitrate, whole blood nitrite and nitrate, and S-nitrosothiols concentrations in plasma remained higher than the initial values until the end of the observation interval.