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. 2011 Jan 10;6(1):e14504. doi: 10.1371/journal.pone.0014504

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Dose proportionality of nitrite in plasma (left panel) and in whole blood (right panel) was assessed using the area under the concentration-time curves AUC_0-last as a function of dose in milligrams. The estimated power coefficient (β₁) for plasma and whole blood nitrite was significantly less than 1, indicating nonlinear pharmacokinetics of nitrite. This nonlinearity could be attributed to the increased nitrite clearance at the higher dose compared with the lowest dose, which strongly suggests that nitrite is much more rapidly removed from the body at higher doses.