Table 2. Baseline characteristics of healthy subjects: nitric oxide (NO) metabolome.

Subject Number	Plasma NO2 µmol/L	Plasma NO3 µmol/L	Plasma SNO nmol/L	WholeBlood NO2 µmol/L	Whole Blood NO3 µmol/L	RBC NO2 µmol/L	RBC NO3 µmol/L
1	0.15	11.1	49.6	0.06	28.27
2	0.07	13.28	35.2	0.23	24.65
3	0.13	11.58	35.2	0.34	14.82
4	0.24	15.41	22.8	0.22	15.23
5	0.13	42.34	28.8	0.41	58.51
6	0.14	43.63	46.3	0.42	62.99
7*	0.11	14.23	30.11	0.28	14.11	0.2	14.11
8 †	0.33	27.22	18.93	0.24	27.37	0.3	23.84
9*	0.52	15.6	17.85	0.35	15.32	0.48	14.19
10*	0.16	12.29	22.77	0.16	40.65	0.39	20.26
11†	0.93	11.78	28.88	0.03	20.15	0.49	12.32
12†	0.13	9.13	15.8	0.15	10.26	0.29	8.61
Mean	0.25	18.97	29.35	0.24	27.69	0.36	15.56
SD	0.25	12.1	10.78	0.13	17.56	0.12	5.54

*maximal tolerated dose (MTD).

^†dose limiting toxicity (DLT).

MABP, mean arterial blood pressure.

MetHb, methemoglobin.

RBC, red blood cells.

NO₂, nitrite.

NO₃, nitrate.

SNO, S-nitrosothiols.

SD, standard deviation.