Table 3. Characteristics of subjects at 12 hours after cessation of intravenous sodium nitrite infusion.

Subject Number	Dose µg/kg/hr	MABP mmHg	MetHb %	Plasma NO2 µmol/L	Plasma NO3 µmol/L	Plasma SNO nmol/L	Whole Blood NO2 µmol/L	Whole Blood NO3 µmol/L	RBC NO2 µmol/L	RBC NO3 µmol/L
1	4.2	101	0.5	0.11	6.99	31.21	0.18	19.29
2	8.3	102	0.7	0.06	16.31	34.18	0.14	14.83
3	16.7	88	0.8	0.11	15.25	26.79	0.11	15.05
4	33.4	88	0.6	0.13	15.51	32.91	0.24	23.73
5	66.8	102	0.6	0.24	12.34	28.2	0.39	18.24
6	133.4	80	0.4	0.2	22.78	24.12	0.33	51.09
7*	266.9	96	0.6	0.12	12.58	34.39	0.12	11.07	0.29	7.31
8†	533.8	91	0.9	0.17	18.52	19.42	0.69	43.79	0.34	21.21
9*	266.9	72	0.9	0.09	11.37	14.58	0.44	28.04	0.32	13.01
10*	266.9	97	0.6	0.11	29.64	18.88	0.33	34.52	0.54	23.4
11†	445.7	105	1	0.11	33.56	36.57	0.38	51.01	0.37	32.02
12†	445.7	88	0.8	0.01	7.68	54.98	0.26	18.02	0.20	9.68
Mean		93	0.7	0.12	16.88	29.69	0.3	27.4	0.34	17.77
SD		10	.2	0.06	8.18	10.59	0.17	14.36	0.11	9.42

7*The measurements were assessed at 12 hours after second (half-dose) infusion cessation.

*maximal tolerated dose (MTD).

^†dose limiting toxicity (DLT).

MABP, mean arterial blood pressure.

MetHb, methemoglobin.

RBC, red blood cells.

NO₂, nitrite.

NO₃, nitrate.

SNO, S-nitrosothiols.

SD, standard deviation.