Table 3.
Genotype frequencies and association tests of rs738409 in PNPLA3 in patients with NAFLD and control subjects
| Genotype CC/CG/GG | Risk allele (G) frequency | P value (additive model) | OR (95% CI) | HWE | |||||
|---|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted for age and gender | Adjusted for age, gender and BMI | Heterogyotes | Homogyotes | Additive model * | P value | |||
| NAFLD vs. control | |||||||||
| NAFLD | 45/111/97 | 0.60 | 9.4 × 10-10 | 1.9 × 10-8 | 0.00087 | 1.46 (0.98 - 2.16) | 3.63 (2.36 - 5.57) | 1.73 (1.25 - 2.38) | 0.18 |
| Control | 175/296/104 | 0.44 | 0.28 | ||||||
| NASH vs. control | |||||||||
| NASH | 26/85/78 | 0.64 | 1.8 × 10-11 | 5.7 × 10-10 | 0.00082 | 1.93 (1.20 - 3.12) | 5.05 (3.04 - 8.37) | 2.00 (1.33 - 3.00) | 0.71 |
| Control | 175/296/104 | 0.44 | 0.28 | ||||||
| NASH vs. simple steatosis | |||||||||
| NASH | 26/85/78 | 0.64 | 0.0083 | 0.010 | 0.021 | 2.39 (1.14 - 4.99) | 3.00 (1.38 - 6.51) | 1.65 (1.08 - 2.51) | 0.71 |
| Simple steatosis |
19/26/19 | 0.50 | 0.13 | ||||||
| Simple steatosis vs. control | |||||||||
| Simple steatosis |
19/26/19 | 0.50 | 0.18 | 0.24 | 0.16 | 0.81 (0.44 - 1.50) | 1.68 (0.85 - 3.32) | 1.37 (0.88 - 2.14) | 0.13 |
| Control | 175/296/104 | 0.44 | 0.28 | ||||||
CI, confidence interval; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; HWE, Hardy-Weinberg equilibrium; OR, odds ratio. * The OR was adjusted simultaneously for age, gender, and BMI using the additive model.