Table 5.
Multiple linear regression analysis for AST, ALT, triglycerides, ferritin, hyaluronic acid, steatosis grade, and fibrosis stage
| Explanatory variable | Subjects | Independent variable | β | SE | P value |
|---|---|---|---|---|---|
| AST | NAFLD | Genotype (additive model, 0/1/2) | 10.165 | 2.606 | 0.00013 |
| Age (year) | -0.162 | 0.153 | 0.29 | ||
| Gender (Man/Women, 1/0) | -4.967 | 4.335 | 0.25 | ||
| BMI (kg/m2) | 0.711 | 0.380 | 0.063 | ||
| Control | Genotype (additive model, 0/1/2) | 0.567 | 0.466 | 0.23 | |
| Age (year) | 0.176 | 0.022 | 4.2 × 10-14 | ||
| Gender (Man/Women, 1/0) | 0.226 | 0.775 | 0.77 | ||
| BMI (kg/m2) | 0.120 | 0.167 | 0.47 | ||
| ALT | NAFLD | Genotype (additive model, 0/1/2) | 18.977 | 4.171 | 9.1 × 10-6 |
| Age (year) | -1.125 | 0.244 | 7.1 × 10-6 | ||
| Gender (Man/Women, 1/0) | 7.571 | 6.938 | 0.28 | ||
| BMI (kg/m2) | 0.991 | 0.608 | 0.10 | ||
| Control | Genotype (additive model, 0/1/2) | 0.417 | 0.477 | 0.38 | |
| Age (year) | 0.120 | 0.023 | 2.5 × 10-7 | ||
| Gender (Man/Women, 1/0) | 2.131 | 0.793 | 0.0076 | ||
| BMI (kg/m2) | 0.370 | 0.171 | 0.031 | ||
| Triglycerides | NAFLD | Genotype (additive model, 0/1/2) | -0.050 | 0.017 | 0.0035 |
| Age (year) | -0.003 | 0.001 | 0.0051 | ||
| Gender (Man/Women, 1/0) | 0.102 | 0.023 | 0.00038 | ||
| BMI (kg/m2) | -0.001 | 0.002 | 0.66 | ||
| Ferritin | NAFLD | Genotype (additive model, 0/1/2) | 0.107 | 0.043 | 0.014 |
| Age (year) | 0.005 | 0.002 | 0.056 | ||
| Gender (Man/Women, 1/0) | 0.298 | 0.069 | 2.9 × 10-5 | ||
| BMI (kg/m2) | 0.009 | 0.006 | 0.11 | ||
| Hyaluronic acid | NAFLD | Genotype (additive model, 0/1/2) | 0.023 | 0.036 | 0.52 |
| Age (year) | 0.016 | 0.002 | 1.6 × 10-12 | ||
| Gender (Man/Women, 1/0) | -0.010 | 0.059 | 0.87 | ||
| BMI (kg/m2) | 0.014 | 0.005 | 0.0047 | ||
| Steatosis grade | NAFLD | Genotype (additive model, 0/1/2) | 0.041 | 0.059 | 0.48 |
| Age (year) | -0.010 | 0.003 | 0.0037 | ||
| Gender (Man/Women, 1/0) | -0.106 | 0.098 | 0.28 | ||
| BMI (kg/m2) | 0.022 | 0.009 | 0.010 | ||
| Fibrosis stage | NAFLD | Genotype (additive model, 0/1/2) | 0.211 | 0.082 | 0.011 |
| Age (year) | 0.013 | 0.005 | 0.0058 | ||
| Gender (Man/Women, 1/0) | 0.184 | 0.136 | 0.18 | ||
| BMI (kg/m2) | 0.046 | 0.012 | 0.00016 | ||
AST, aspartate transaminase; ALT, alanine transaminase; BMI, body mass index; NAFLD, nonalcoholic fatty liver disease. The values of triglycerides, ferritin, and hyaluronic acid were logarithmically transformed.