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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: J Neurochem. 2010 Dec 13;116(3):406–414. doi: 10.1111/j.1471-4159.2010.07121.x

Figure 6.

Figure 6

CCL2 enhances EPSCs via presynaptic mechanisms. A. Example traces of sEPSCs recorded from a rat CA1 pyramidal neuron. Note that CCL2 increased the frequency of sEPSC occurrence. B. Histograms of the frequency of sEPSC events recorded from the same CA1 pyramidal neuron as shown in A. CCL2 significantly increased the frequency of sEPSCs (p < 0.05). Vh= −70mV. C. The eEPSC amplitude distributions before and during bath application of CCL2 on the same neuron as shown in A. CCL2 decreased the number of failures of eEPSCs. The mean amplitudes were 9.32 ± 0.46 pA and 9.86 ± 0.56 pA, respectively. D. Cumulative amplitude distribution of sEPSCs before (□), during (●) and after (△) perfusion of CCL2. (Kolmogorov–Smirnov test, p > 0.05). E. Averaged date from 5 experiments showing that CCL2 had no significant effects on mean amplitude of sEPSCs (left two bars), but it significantly increased mean frequency of sEPSC occurrence. These results indicate a presynaptic site of CCL2 action.