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LARGE overexpression enhances pikachurin binding in POMGnT1 knockout cells.
Wildtype and POMGnT1-deficient neural stem cells were infected with Ad-LARGE. Pikachurin overlay and IIH6C4 immunoblot analysis were then carried out on glycoproteins isolated from cell lysates. Pikachurin binding was dramatically increased by LARGE overexpression in both wildtype and POMGnT1-deficient neural stem cells.
