Table 1.
Biometric and echocardiographic properties in lean and ob/ob obese mice with or without chronic TUDCA treatment (50 mg/kg/d for 5 wks; p.o.)
| Lean | Lean+TUDCA | Obese | Obese+TUDCA | |
|---|---|---|---|---|
| Body Weight (g) | 30.2 ± 0.8 | 29.5 ± 0.8 | 59.2 ± 1.6* | 55.9 ± 1.0* |
| Heart Weight (mg) | 223 ± 10 | 193 ± 11 | 334 ± 19* | 222 ± 16*# |
| HW/BW (mg/g) | 7.41 ± 0.43 | 6.55 ± 0.33 | 5.66 ± 0.36* | 3.98 ± 0.29*# |
| Liver Weight (g) | 1.52 ± 0.06 | 1.35 ± 0.05 | 3.96 ± 0.29* | 3.61 ± 0.15* |
| LW/BW (mg/g) | 50.5 ± 2.6 | 46.2 ± 2.2 | 64.5 ± 2.0 | 67.1 ± 5.2 |
| Kidney Weight (g) | 0.46 ± 0.01 | 0.37 ± 0.03 | 0.75 ± 0.03* | 0.40 ± 0.03*# |
| KW/BW (mg/kg) | 15.4 ± 0.5 | 12.6 ± 0.9 | 12.7 ± 0.5 | 7.1 ± 0.4*# |
| Systolic BP (mmHg) | 105.6 ± 4.2 | 100.1 ± 2.3 | 165.8 ± 9.9* | 135.6 ± 5.7*# |
| Diastolic Diameter (mm) | 2.45 ± 0.32 | 2.49 ± 0.30 | 3.18 ± 0.36* | 2.29 ± 0.23# |
| Systolic Diameter (mm) | 1.31 ± 0.16 | 1.53 ± 0.27 | 1.40 ± 0.23 | 1.22 ± 0.11 |
| Diastolic Wall Thickness (mm) | 1.01 ± 0.09 | 1.17 ± 0.16 | 1.01 ± 0.05 | 1.05 ± 0.04 |
| Heart Rate (beat per minute) | 462 ± 24 | 459 ± 32 | 516 ± 40 | 573 ± 34 |
| LV Mass (mg) | 43.2 ± 6.1 | 49.2 ± 7.1 | 88.9 ± 14.5* | 63.1 ± 4.5*# |
| Normalized LV Mass (mg/g) | 1.41 ± 0.19 | 1.59 ± 0.26 | 1.52 ± 0.29 | 1.11 ± 0.08 |
| Fractional Shortening (%) | 45.2 ± 2.7 | 42.0 ± 1.5 | 34.8 ± 4.9* | 46.2 ± 1.1# |
HW: heart weight; LW: Liver weight; KW: Kidney weight. Mean ± SEM, n = 5–7 mice per group,
*
p < 0.05 vs. lean group;
#
p < 0.05 vs. obese group.