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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Neurosci Lett. 2010 Dec 2;489(1):43–47. doi: 10.1016/j.neulet.2010.11.063

Fig. 2.

Fig. 2

TLR2 is required for the activation of microglia following chronic morphine administration. Wild type (WT) and TLR2 KO male mice aged 9–10 week were implanted with a 25 mg morphine pellet or a placebo pellet subcutaneously under isoflurane anesthesia as described under materials and methods. Four days after pellet implantation, the NAcs were harvested and total RNA was isolated. The activation level of microglia was quantified by measuring the transcript levels of CD11b by real time RT-PCR. Means and SEs were calculated from 5 to 7 mice per group. * p < 0.01 compared with indicated groups.