AG129 mice were treated with (A) either 40mg/kg of ribavirin, 75mg/kg of CM-10-18 or a combination of the two compounds; (B) 40mg/kg of ribavirin, doses of CM-10-18, or combination of two compounds, as indicated. PBS was given to control mice. 3 days after infection, the blood samples were drawn to determine virus titer by plaque assay. Values represent average and standard deviation from results obtained from 6 mice per treatment group. P values were calculated using student t test. * indicate P values compared to PBS control.