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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Free Radic Biol Med. 2010 Nov 11;50(2):281–294. doi: 10.1016/j.freeradbiomed.2010.11.006

Figure 5.

Figure 5

U18666A-, imipramine- and clozapine-mediated inhibition of apoptosis initiated by photoirradiation of NPe6-sensitized cultures. 1c1c7 cultures were treated with nothing (NT) or different concentrations of U18666A (UA), imipramine (IPM), or clozapine (CZP) for ~24 h prior to being sensitized with 33 µM NPe6. Sensitized cultures were photoirradiated 1 h later for 80s. Cultures were harvested for analyses of DEVDase activities (A–C) or procaspase-9 and -3 cleavage (D) at indicated times after photoirradiation. Data in panels A–C represent means of triplicate analyses performed with the lysate of a single culture. The studies reported in panels A–C were repeated minimally a second time with similar results. The western blots in panel D employed 25 µg of cellular lysate per lane.