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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Arch Biochem Biophys. 2010 Oct 18;505(2):144–154. doi: 10.1016/j.abb.2010.10.013

Fig. 1. Structural and functional domains of TnT.

Fig. 1

This illustration outlines the structural and functional regions of TnT. The high resolution structure of partial troponin complex including a C-terminal segment of TnT that interacts with TnI and TnC as determined with crystallography is redrawn from published data (19). The chymotryptic cleavage site between the T1 and T2 fragments, the sites of cleavage in cardiac TnT by calpain I to selectively remove the N-terminal variable region (121) and by caspase 3 (120), the position of the Amish nemaline myopathy (ANM) nonsense mutation (52), and the alternatively spliced C-terminal variable region of fast TnT are indicated with arrows. The recently refined locations of the two tropomyosin-binding sites (24) are outlined.