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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Arch Biochem Biophys. 2010 Oct 18;505(2):144–154. doi: 10.1016/j.abb.2010.10.013

Fig. 2. Evolutionary lineages of TnI-TnT genes.

Fig. 2

The evolution of TnI, TnT and the linked isoform gene pairs was established from data of sequence analysis, immunological distance, and experimental examination of evolutionarily suppressed conformational states (9). This evolutionary lineage began from a TnI-like ancestor gene that was duplicated to form a linked fast TnI-fast TnT-like gene pair. A later duplication event resulted in the emergences of a slow TnI-cardiac TnT-like gene pair that was further duplicated to give rise the present-day slow TnI-cardiac TnT and cardiac TnI-slow TnT gene pairs. This figure is duplicated with permission from a part of a figure published previously (9).