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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Arch Biochem Biophys. 2010 Oct 18;505(2):144–154. doi: 10.1016/j.abb.2010.10.013

Fig. 3. Alternatively spliced exons of mammalian and avian fast, cardiac and slow TnT genes.

Fig. 3

The exon segments for the coding region of fast, cardiac and slow TnT genes are shown with the alternatively spliced exons represented by the filled boxes, among which the developmentally regulated exons are in solid black. The w, x (P), and y exons illustrated in the fast TnT structure are only found in avian species. The outlines demonstrate that the C-terminal and middle regions of TnT are highly conserved among the three fiber type-specific isoforms whereas the N-terminal region is highly variable. The alternative splicing of exon 6 in slow TNT gene using two acceptor sites is indicated with an arrowhead. The calpain I cleavage site that selectively removes the N-terminal variable region of cardiac TnT in stress conditions (121), the caspase 3 cleavage site in cardiac TnT (120), and the chymotrypsin cleavage site used to generate the T1 and T2 experimental fragments of fast TnT (10) are also indicated with arrowheads