. 2010 Jun 26;43(1):115–121. doi: 10.1007/s12031-010-9411-4

Table 1.

Effect of the melanin-concentrating hormone receptor 1 antagonists in animal models of anxiety-related behaviors

Animal models of anxiety-related behaviors
MCH1R antagonists	rEPM	rSI	rUSV	rVCT	mEPM	mSIH	mL/D	mNSF	mMB	gpSIV
SNAP-7941		Anxiolytic^a or no effect^b	Anxiolytic^b	Anxiolytic^b					Anxiolytic^b	Anxiolytic^a
SNAP-94847		Anxiolytic^c				Anxiolytic^c,e	Anxiolytic^d	Anxiolytic^d
ATC0065	Anxiolytic^f					Anxiolytic^f			No effect^f
ATC0175	Anxiolytic^f	Anxiolytic^f				Anxiolytic^f			No effect^f
GW803430 (=GW3430)		No effect^b	Anxiolytic^b	Anxiolytic^b	Anxiolytic^g	Anxiolytic^g			Anxiolytic^b,h

rEPM rat elevated plus maze with swim stress, rSI rat social interaction, rUSV rat ultrasonic vocalization, rVCT rat vogel conflict test, mEPM mouse elevated plus maze, mSIH mouse stress-induced hyperthermia, mL/D mouse light–dark, mNSF mouse novelty-suppressed feeding, mMB mouse marble burying, gpSIV guinea pig pup separation-induced vocalization

^aBorowsky et al. (2002)

^b Millan et al. (2008)

^c McBriar (2006)

^dDavid et al. (2007)

^eSmith et al. (2009)

^fChaki et al. (2005)

^gSmith et al. (2006)

^hGehlert et al. (2009)