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Cardiorenal immunohistochemistry of TGF-β1. TGF-β1-stained spots are observed in the myocardium (upper panels) and coronary artery (middle panels) in Ang II-infused wild-type mice (upper and middle panels). Macroscopic renal injury and TGF-β1-stained renal glomerulus are found in Ang II-infused mice, especially eNOS−/− mice (lower panels). Pitavastatin treatment attenuates cardiorenal TGF-β1 expression in Ang II-infused mice. Modified from the article by Yagi et al. [37].
