Table 2.
Highest differentially expressed genes from whole genome Microarray analysis.
| GS | Gene name | Gene molecular function/Gene biological process | FDR | FC | Up/Down |
|---|---|---|---|---|---|
| ANKRD22 | Ankyrin repeat domain 22 | Data not found | 0 | 4.5 | Up |
| BATF2 | Basic leucine zipper transcription factor, ATF-like 2 | DNA binding and transcription factor activity | 0 | 2.6 | Up |
| CD38 | CD38 molecule | Hydrolase activity in hydrolyzing N-glycosyl compounds and lyase activity | 0 | 2.1 | Up |
| DCLRE1B | DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) | Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process | 0 | 1.9 | Up |
| EGR1 | Early growth response 1 | RNA binding, DNA binding, and transcription factor activity | 0 | 4.9 | Up |
| EPSTI1 | Epithelial stromal interaction 1 (breast) | Data not found | 0 | 3.2 | Up |
| FAM26F | Family with sequence similarity 26, member F | Data not found | 0 | 2.6 | Up |
| FCGR1B | Fc fragment of IgG, high affinity Ib, receptor (CD64) | Receptor activity | 0 | 2.8 | Up |
| FLJ11783 | Data not found | Data not found | 0 | 0.4 | Down |
| GNB4 | Guanine nucleotide binding protein (G protein), beta polypeptide 4 | GTPase activity and protein binding | 0 | 2.3 | Up |
| IFI44 | Interferon-induced protein 44 | Data not found | 0 | 3.1 | Up |
| IFI44L | Interferon-induced protein 44-like | Data not found | 0 | 4.8 | Up |
| IFI6 | In multiple clusters | Immune system process | 0 | 2.9 | Up |
| IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | Response to interferon-gamma and response to stimulus | 0 | 7.1 | Up |
| IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 | Response to interferon-gamma and response to stimulus | 0 | 4.8 | Up |
| IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 | Response to interferon-gamma and response to stimulus | 0 | 7.4 | Up |
| IFITM2 | Interferon-induced transmembrane protein 2 (1-8D) | Immune system process | 0 | 2.9 | Up |
| IFITM3 | Interferon-induced transmembrane protein 3 (1-8U) | Immune system process | 0 | 2.6 | Up |
| IFITM4P | Leukocyte Ig-like receptor, subfamily A (with TM domain), member 2 | Data not found | 2 | 2.0 | Up |
| ISG15 | Leukocyte Ig-like receptor, subfamily A (with TM domain), member 5 | Ligase activity, apoptosis, and protein metabolic process | 2 | 4.4 | Up |
| LY6E | Lymphocyte antigen 6 complex, locus E | Data not found | 0 | 2.8 | Up |
| MMP8 | Matrix metallopeptidase 8 (neutrophil collagenase) | Peptidase activity and protein metabolic process | 0 | 5.2 | Up |
| MX1 | Influenza virus resistance 1, IFN-inducible protein p78 (mouse) | GTPase activity, protein binding, intracellular protein transport, and endocytosis | 0 | 3.0 | Up |
| OAS2 | 2′–5′-oligoadenylate synthetase 2, 69/71 kDa | Nucleotidyltransferase activity, nucleic acid binding, response to interferon-gamma, and response to stimulus | 0 | 3.2 | Up |
| PLAC8 | Placenta-specific 8 | Data not found | 0 | 3.0 | Up |
| PLSCR1 | Phospholipid scramblase 1 | Immune system process, lipid transport, lipid metabolic process, and blood coagulation | 0 | 2.4 | Up |
| RSAD2 | Radical S-adenosyl methionine domain containing 2 | Data not found | 0 | 5.6 | Up |
| SCARB2 | Scavenger receptor class B, member 2 | Macrophage activation, lipid transport, apoptosis, signal transduction, cell adhesion, lipid metabolic process | 0 | 2.3 | Up |
| SIGLEC1 | Sialic acid binding Ig-like lectin 1, sialoadhesin | B cell mediated immunity, signal transduction, cell-cell adhesion, and response to stimulus | 0 | 7.8 | Up |
| CXCL10 | Chemokine (C-X-C motif) ligand 10 | Macrophage activation, cell-cell signaling, cell motion, signal transduction, and cellular defense response | 1 | 3.4 | Up |
| EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Immune system process, cell cycle, protein metabolic process, and response to stress | 1 | 2.1 | Up |
| LAP3 | Leucine aminopeptidase 3 | Protein metabolic process | 1 | 3.0 | Up |
| LCP1 | Lymphocyte cytosolic protein 1 (L-plastin) | Structural constituent of cytoskeleton, cytoskeletal protein binding, and cellular component morphogenesis | 1 | 1.9 | Up |
| SECTM1 | Secreted and transmembrane 1 | Data not found | 1 | 1.9 | Up |
| SERPING1 | Serpin peptidase inhibitor, clade G, member 1, (Angioedema) | Protein binding, peptidase inhibitor activity, and protein metabolic process | 1 | 3.0 | Up |
| STXBP2 | Syntaxin binding protein 2 | Neurotransmitter secretion, intracellular protein transport, exocytosis, and synaptic transmission | 1 | 2.1 | Up |
| SULT1A1 | Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | Transferase activity, sulfur metabolic process, and lipid metabolic process | 1 | 2.1 | Up |
| TBRG1 | Transforming growth factor beta regulator 1 | Receptor binding | 1 | 0.4 | Down |
| BLOC1S1 | Biogenesis of lysosome-related organelles complex-1, subunit 1 | DNA binding and transcription factor activity | 2 | 1.9 | Up |
| BST2 | Bone marrow stromal cell antigen 2 | Data not found | 2 | 2.0 | Up |
| CCDC84 | Coiled-coil domain containing 84 | Data not found | 2 | 0.4 | Down |
| CDC14A | CDC14 cell division cycle 14 homolog A (S. cerevisiae) | Mitosis, phosphate metabolic process, and protein metabolic process | 2 | 0.5 | Down |
| FLJ32679 | In multiple clusters | Data not found | 2 | 0.5 | Down |
| FLJ38379 | Hypothetical protein FLJ38379 | Data not found | 2 | 0.4 | Down |
| HERC5 | Hect domain and RLD 5 | Protein metabolic process, ectoderm development, mesoderm development, and skeletal system development | 2 | 3.6 | Up |
GS: Gene Symbol; FDR: false discovery rate; FC: fold change; Up/Down: regulation in advanced versus normal or mild CAV.