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. 2010 Dec 28;2010:719696. doi: 10.1155/2010/719696

Table 3.

Gene ontology categories enriched by genes expressed differentially between patients with and without advanced CAV.

Regulation in Adv-CAV Number of genes GO category type Exemplary GO categories
Up-/Down-regulated 291 Biological process GO:0006955 immune response
GO:0002376 immune system process
GO:0051707 response to other organism
GO:0009607 response to biotic stimulus
GO:0006954 inflammatory response
GO:0050896 response to stimulus
GO:0009615 response to virus
GO:0009611 response to wounding
GO:0006952 defense response
GO:0045087 innate immune response
GO:0009605 response to external stimulus
GO:0042116 macrophage activation
GO:0006950 response to stress
Molecular function GO:0045408 regulation of interleukin-6 biosynthetic process
GO:0007249 I-kappaB kinase NF-kappaB cascade
GO:0007243 protein kinase cascade
GO:0007009 plasma membrane organization and biogenesis
GO:0032635 interleukin-6 production
GO:0042226 interleukin-6 biosynthetic process
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0009057 macromolecule catabolic process
GO:0009595 detection of biotic stimulus
GO:0007250 activation of NF-kappaB-inducing kinase
Up-Regulated 170 Biological process None
Molecular function None
Down-Regulated 123 Biological process GO:0006955 immune response
GO:0002376 immune system process
GO:0051707 response to other organism
GO:0009607 response to biotic stimulus
GO:0006954 inflammatory response
GO:0050896 response to stimulus
GO:0009615 response to virus
GO:0009611 response to wounding
GO:0006952 defense response
GO:0045087 innate immune response
GO:0009605 response to external stimulus
GO:0042116 macrophage activation
GO:0006950 response to stress
GO:0048518 positive regulation of biological process
GO:0002250 adaptive immune response
Molecular function GO:0045408 regulation of interleukin-6 biosynthetic process
GO:0007249 I-kappaB kinase NF-kappaB cascade
GO:0007243 protein kinase cascade
GO:0007009 plasma membrane organization and biogenesis
GO:0032635 interleukin-6 production
GO:0042226 interleukin-6 biosynthetic process
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0009057 macromolecule catabolic process
GO:0009595 detection of biotic stimulus
GO:0007250 activation of NF-kappaB-inducing kinase
GO:0045084 positive regulation of interleukin-12 biosynthetic process

Adv-CAV: advanced cardiac allograft vasculopathy.