Table 3.
Regulation in Adv-CAV | Number of genes | GO category type | Exemplary GO categories |
---|---|---|---|
Up-/Down-regulated | 291 | Biological process | GO:0006955 immune response |
GO:0002376 immune system process | |||
GO:0051707 response to other organism | |||
GO:0009607 response to biotic stimulus | |||
GO:0006954 inflammatory response | |||
GO:0050896 response to stimulus | |||
GO:0009615 response to virus | |||
GO:0009611 response to wounding | |||
GO:0006952 defense response | |||
GO:0045087 innate immune response | |||
GO:0009605 response to external stimulus | |||
GO:0042116 macrophage activation | |||
GO:0006950 response to stress | |||
Molecular function | GO:0045408 regulation of interleukin-6 biosynthetic process | ||
GO:0007249 I-kappaB kinase NF-kappaB cascade | |||
GO:0007243 protein kinase cascade | |||
GO:0007009 plasma membrane organization and biogenesis | |||
GO:0032635 interleukin-6 production | |||
GO:0042226 interleukin-6 biosynthetic process | |||
GO:0045410 positive regulation of interleukin-6 biosynthetic process | |||
GO:0009057 macromolecule catabolic process | |||
GO:0009595 detection of biotic stimulus | |||
GO:0007250 activation of NF-kappaB-inducing kinase | |||
Up-Regulated | 170 | Biological process | None |
Molecular function | None | ||
Down-Regulated | 123 | Biological process | GO:0006955 immune response |
GO:0002376 immune system process | |||
GO:0051707 response to other organism | |||
GO:0009607 response to biotic stimulus | |||
GO:0006954 inflammatory response | |||
GO:0050896 response to stimulus | |||
GO:0009615 response to virus | |||
GO:0009611 response to wounding | |||
GO:0006952 defense response | |||
GO:0045087 innate immune response | |||
GO:0009605 response to external stimulus | |||
GO:0042116 macrophage activation | |||
GO:0006950 response to stress | |||
GO:0048518 positive regulation of biological process | |||
GO:0002250 adaptive immune response | |||
Molecular function | GO:0045408 regulation of interleukin-6 biosynthetic process | ||
GO:0007249 I-kappaB kinase NF-kappaB cascade | |||
GO:0007243 protein kinase cascade | |||
GO:0007009 plasma membrane organization and biogenesis | |||
GO:0032635 interleukin-6 production | |||
GO:0042226 interleukin-6 biosynthetic process | |||
GO:0045410 positive regulation of interleukin-6 biosynthetic process | |||
GO:0009057 macromolecule catabolic process | |||
GO:0009595 detection of biotic stimulus | |||
GO:0007250 activation of NF-kappaB-inducing kinase | |||
GO:0045084 positive regulation of interleukin-12 biosynthetic process |
Adv-CAV: advanced cardiac allograft vasculopathy.