(b) Expression of TNFα, IL-1β, IL-6, and IL-10 cytokines after 15-minute treatment in hypoxic or hyperoxic conditions.

Cytokines (pg/ml)	Saline 8 hrs	Hypoxia 15 min	Hyperoxia 15 min
TNFα (P < .05)	0.39 ± 0.11	0.54 ± 0.29	0.71 ± 0.21
IL-1β	0.29 ± 0.19	0.44 ± 0.15	0.40 ± 0.17
IL-6 (P < .05)	0.21 ± 0.14	0.69 ± 0.20	0.67 ± 0.36
IL-10	0.35 ± 0.19	0.43 ± 0.39	0.39 ± 0.20

Cytokine levels in hypoxic or hyperoxic conditions were elevated. However, a significant increase was observed only for TNFα and IL6 expressions for both hypoxic and hyperoxic groups compared to saline-instilled group.