Table 2.
Primary and secondary SjS mouse models.
| Type of SjS | Mouse Model | Secondary to |
|---|---|---|
| Primary | Aec1Aec2 | — |
| NOD.B10-H2b | — | |
| NFS/sld | — | |
| IQI/Jic | — | |
| CAII immunization | — | |
| PI3K K.O. | — | |
| ID3 K.O. | — | |
| Ar K.O. | — | |
| Ro immunization | — | |
| Aly/aly | — | |
| Secondary | NOD | Autoimmune diabetes |
| NOD.H2h4 | Autoimmune thyroiditis | |
| MRL/lpr | RA, SLE | |
| GVHR | SLE | |
| BAFF Tg | SLE | |
| IL-12 Tg | SLE | |
| IL-14α Tg | SLE | |
| MCMV | SLE | |
| HTLV-1 tax Tg | RA [30] | |
| TGF-β1 K.O. | SLE [31] | |
| IL-6 TgIL-10 Tg | PBC [32]SLE/Neuropathy | |
| TSP-1 K.O. | IBS | |
K.O.: knockout; Tg: transgenic; SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; PBC: primary biliary cirrhosis; IBS: inflammatory bowel disease.