Table 3.
Features of common spontaneous and transgenic mouse models for SjS.
| Characteristic | Autoantibodies | Sjögren's syndrome patient | Spontaneous mouse model | Transgenic mouse model | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NOD | Aec1Aec2 | NZB/ W F1 |
MRL/ lpr |
NFS/ sld |
IQI/ Jic |
Aly/ aly |
HTLV-1 | BAFF | IL-6 | IL-10 | IL-12 | IL-14α | |||
| Anti-Ro/SS-A, Anti-La/SS-B | Yes | Yes | No | No | Yes | Yes | No | — | — | No | — | No | Yes | Yes | |
| Anti-DNA (ANAs) | Yes | Yes | Yes | Yes | Yes | Yes | Yes | — | — | Yes | — | — | Yes | — | |
| Anti-α-fodrin | Yes | Yes | — | — | Yes | Yes | — | — | — | — | — | — | — | — | |
| Anti-β-adrenergic receptor | Yes | Yes | Yes | Yes | Yes | — | — | — | — | — | — | — | — | — | |
| Anti-type3 muscarinic Ach receptor | Yes | Yes | Yes | Yes | Yes | — | — | — | — | — | — | — | — | — | |
| Leukocytic infiltrate | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | |
| - Time of onset (weeks) | 12 | 10 | 16 | 8 | 16 | 8 | 24 | 24 | 52 | 2 | 8 | <16 | 48 | ||
| Dacryoadenitis | Yes | Yes | Yes | Yes | Yes | Yes | Yes | — | Yes | — | — | Yes | Yes | — | |
| Sialadenitis | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | — | Yes | Yes | Yes | |
| Loss secretory function | Yes | Var | Yes | Var | No | Yes | — | — | — | Yes | — | Yes | Var | Var | |
| - Time of onset (weeks) | 20 | 19 | 24 | — | 72 | — | — | — | 52 | — | 8 | 16 | 12 | ||
| - Target organ | S, L | S, L | L | — | S, L | — | — | — | S | — | S, L | S, L | S | ||
| Proinflammatory cytokine product | Yes | Yes | Yes | Yes | Yes | Yes | Yes | — | — | — | Yes | Yes | Yes | Yes | |
Var: variable, male, and female mice differ, –: Not determined, S: Salivary glands, L: Lacrimal glands.