Table 4.
Features of common knockout, immunization, infection, and transplantation chimera mouse models for SjS.
| Characteristic | Autoantibodies | Sjögren's syndrome patient | Knockout (KO) mouse model | Immunization mouse model | Infectionmouse model | Transplantation chimeras | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Id3 | PI3K | TGF-β1 | TSP-1 | Ar | CAII | Ro | CMV | GVHR | |||
| Anti-Ro/SS-A, Anti-La/SS-B | Yes | Yes | Yes | No | Yes | — | — | Yes | Yes | — | |
| Anti-DNA (ANAs) | Yes | — | — | Yes | — | No | — | — | — | Yes | |
| Anti-α-fodrin | Yes | — | — | — | — | Yes | — | — | — | — | |
| Anti-β-adrenergic receptor | Yes | — | — | — | — | — | — | — | — | — | |
| Anti-type3 muscarinic Ach receptor | Yes | — | — | — | — | — | — | — | — | — | |
| Leukocytic infiltrate | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | |
| - Time of onset (weeks) | 8 | 8 | 1 | 24 | 48 | — | 16 | 4 | 28 | ||
| Dacryoadenitis | Yes | Yes | Yes | — | Yes | — | Yes | — | — | — | |
| Sialadenitis | Yes | Yes | Yes | Yes | — | Yes | Yes | Yes | Yes | Yes | |
| Loss of secretory function | Yes | Yes | Yes | Yes | Yes | — | — | Yes | Yes | — | |
| - Time of onset (weeks) | 8 | <8 | >1 | 24 | — | — | 16 | 4 | — | ||
| - Target organ | S, L | S, L | S | L | — | — | S | S | — | ||
| Proinflammatory cytokine product | Yes | — | Yes | Yes | Yes | — | — | — | — | — | |
Var: variable, male, and female mice differ, –: Not determined, S: Salivary glands, L: Lacrimal glands.