Table 2.
Comparison of AD-like phenotypes in transgenic mouse models.
| Mouse model | Genetic background | Transgenes | Plaque onset* | Memory impair# | Ref. |
|---|---|---|---|---|---|
| Tg2576 | FVB/N | Prion promoted-APPswe (K670N, M671L) | 7-8 | 6 | [9, 12] |
| PS1Tg2576 | Unknown | PDGF ¶promoted-PS1 (M146L) × Prion promoted-APPswe | 6 | 15-16 | [13, 27] |
| PS2APP | B6D2F1 | Prion promoted-PS2 (N141I) × thy1 promoted-APPswe | 5 | 8 | [28] |
| PS2Tg2576 | B6 × 129S6 | CAG† promoted-PS2 (N141I) × Prion promoted-APPswe | 2-3 | 4-5 | This article |
*Month of age. Previous reported onset of typical amyloid deposition. #Month of age. Previous reports of spatial learning and memory impairment in the Morris water maze. ¶PDGF, platelet-derived growth factor promoter. †CAG, cytomegalovirus early enhancer coupled with chicken β-actin promoter.