Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Dec 29;2011:640610. doi: 10.1155/2011/640610

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2011 Atsuko Masumi.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Two different functions of interferon regulatory factor-2 (IRF-2) through its acetylation by HAT. (a) During TPA-induced cell differentiation, IRF-2 binds histone acetylases, p300, and PCAF and inhibits core histone acetylation, resulting in the inhibition of IFN-inducible genes. (b) IRF-2 binds to PCAF and is acetylated. Acetylated IRF-2 is recruited to nuclear protein, nucleolin. The IRF-2/PCAF/nucleolin complex contributes to cell growth through the activation of ISRE-like site in the H4 gene promoter.