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Time course of whole-body fluorescence imaging of Lewis lung carcinoma-GFP angiogenesis in the mouse footpad. The GFP-expressing tumor cells were injected into the footpad of nude mice and whole-body imaged as described in Materials and Methods. (A) Day 3. (B) Day 6. (C) Day 8. (D) Day 13. (E) Quantitative graph of microvessel density as a function of time. (Bar = 500 μm.)
