Table 1.
CIN in Human Conceptions During the Prenatal Development
| Developmental Stage | Tissue | Type of CIN | Normal Variation | Pathological Condition | Key Refs |
|---|---|---|---|---|---|
| Preimplantation embryos | NA | Aneuploidy | + | + | [21, 24, 27] |
| NA | Aneuploidy/structural abnormalities | + | ? | [7] | |
| Fetuses at 7-12 weeks gestation | Chorionic villi | Aneuploidy | + | - | [6] |
| Brain | Aneuploidy | + | ? | [5, 6] | |
| Skin | Aneuploidy | + | - | [6] | |
| Ovarian tissue | Aneuploidy | + | - | [25] | |
| Spontaneous abortions (7-15 weeks gestation) | Chorionic villi | Chromosomal mosaicism (aneuploidy) | - | + | [28] |
| Prenatal diagnosis (~7-12 weeks gestation) (choriocentesis) | Chorionic villi Placenta | Chromosomal mosaicism (aneuploidy) | + | - | [30] |
| Prenatal diagnosis at 20th week gestation | 14 different tissues | Derivative chromosomes (marker chromosomes) | - | + | [31] |
NA — not applicable.