Figure 2.

Results of MG cell adaptation simulation. Membrane potential (solid line), dendritic spike threshold (dashed line), and synaptic weights (separate dots) for a model MG cell. (A) The idealized waveform represents the corollary discharge with the parallel fiber synaptic strengths, given a random initial weight distribution (arbitrary units where maximum weight = 1.0 and maximum potential V = 100). The horizontal location of the weights represents the delay following the EOD motor command where input begins, and the height represents the synaptic strength. (B) After adaptation, the spike-timing-dependent learning rule adjusted the synaptic weights. The synaptic weights for parallel fibers onto the model MG cell are depressed, resulting in a cancelation of the corollary discharge-evoked EPSP.