Table 1.

Properties of site-specific crosslinks of polynuclear Pt compounds (see Fig. 1 for structures)

	Site-specific adductsa
Compound	IXL, direction	Unwinding/°	Bending/°	HMG protein
Cisplatin	1,2	6	40–45	Yes
I (BBR3005)	1,4 5′ → 5′	9	10	No
II (BBR3571)	1,4 5′ → 5′
	1,4 3′ → 3′
IV (BBR3464)	1,2 3′ → 3′	—	—	—
	1,4 3′ → 3′	9	15	No
	1,4 5′ → 5′	10	21	No
	1,6 5′ → 5′	—	—	—

^aFrom ref. 21, 23 and 24.