Fig. 2.

Pairwise proximity matrixes for pepleomycin and simvastatin. Proximity matrices from Random Forest are defined as the number of instances in which two cases (cell lines) are assigned to the same terminal node of a tree, normalized over the [0, 1] interval. Proximity between a case and itself is not a meaningful value so these instances on the diagonal are set to zero (A1) proximity matrix for pepleomycin before reduction of cell-lines by Equation (1). (A2) Proximity matrix for pepleomycin after removal of outlying cell lines. (B1) Proximity matrix for simvastatin. (B2) Proximity matrix for simvastatin after removal of outlying cell lines.