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. Author manuscript; available in PMC: 2011 Oct 29.
Published in final edited form as: Chem Biol. 2010 Oct 29;17(10):1101–1110. doi: 10.1016/j.chembiol.2010.07.017

Figure 1. Teichoic acids are a major component of the gram-positive cell wall and the pathway for ribitol-phosphate wall teichoic acids has been proposed.

Figure 1

(A) A schematic of the Gram-positive cell wall depicting membrane anchored lipoteichoic acid and peptidoglycan anchored wall teichoic acid (WTA) polymers.

(B) The chemical structure of ribitol-phosphate wall teichoic acid as found in S. aureus and B. subtilis W23 (y = 1–2, z = 20–40). The tailoring modifications on the main chain hydroxyls are omitted for clarity.

(C) Lazarevic et al. (2002) proposed the biosynthetic pathway depicted above for polyribitol-phosphate WTAs. The numbers in parentheses correspond to the substrates utilized in our in vitro experiments (see Figure 2 for chemical structures).