Figure 4.
Histologic examination of liver tissue 60 minutes after reperfusion (hematoxylin and eosin, X25). (A) Untreated control liver, Although basic architecture was preserved, severe sinusoidal congestion, mild sinusoidal cell derangement, and mild hepacocyte injury and necrosis were found. (B) The liver treated with FK409. Although mild sinusoidal congestion and sinusoidal cell derangement were recognized, neither hepatocyte injury nor necrosis was found. (C) The liver treated with L-arginine. Mild sinusoidal cell derangement was found, but sinusoidal congestion and hepatocyte injury and necrosis wur not observed.