Table 1.

Alanine Aminotransferase, Lactate Dehydrogenase, Total Bile Acid, and Hyaluronic Acid Levels After Reperfusion

Measurement and group	Before ischemia	End of ischemia	After Reperfusion
Measurement and group	Before ischemia	End of ischemia	l h	3 h	6 h	12 h	24 h
ALT
CT	32 ± 4	33 ± 3	4,961 ± 798	6,576 ± 1,007	9,332 ± 1,128	13,563 ± 1,379	12,680 ± 1,451
LA	17 ± 3	21 ± 2	1,610 ± 373^*	2,277 ± 503^*	2,732 ± 601^*	3,214 ± 661^*	2,378 ± 517^*
FK	19 ± 6	26 ± 15	2,202 ± 758^*	2,814 ± 1139^*	3,766 ± 1,568^*	3,410 ± 1,521^*	2,789 ± 1,388^*
LDH
CT	81 ± 16	173 ± 27	3,385 ± 474	3,128 ± 479	2,906 ± 559	3,046 ± 634	1,441 ± 216
LA	72 ± 12	185 ± 52	1,391 ± 355^*	1,250 ± 304^*	968 ± 254^*	693 ± 186^*	261 ± 49^*
FK	121 ± 57	165 ± 99	1,991 ± 704	1,628 ± 623^*	1,142 ± 314^*	603 ± 192^*	343 ± 128^*
TBA
CT	0.3 ± 0.3	29.9 ± 6.3	48.5 ± 11.7	100.2 ± 11.0	133.8 ± 11.8	124.3 ± 13.1	175.4 ± 39.0
LA	—	—	70.6 ± 19.4	87.6 ± 25.1	58.0 ± 35.2^*	41.2 ± 22.4^*	20.2 ± 6.7^*
FK	—	—	49.6 ± 10.8	83.6 ± 23.2	68.8 ± 24.4^*	53.2 ± 13.4^*	53.4 ± 24.5^*
HA
CT	16.7 ± 6.5	348.9 ± 68.1	78.1 ± 27.5	61.4 ± 17.4	82.4 ± 30.9	112.6 ± 23.8	515.3 ± 167.5
LA	9.4 ± 4.3	371.2 ± 113.5	28.8 ± 6.5	42.3 ± 22.7	39.4 ± 13.6	36.2 ± 10.3^*	201.1 ± 50.0
FK	12.2 ± 7.5	261.0 ± 84.8	22.8 ± 13.1	74.0 ± 33.2	55.9 ± 26.8	47.1 ± 13.4^*	188.4 ± 60.2^*

ALT, alanine aminotransferase; CT, untreated control (n = 10); FK, group treated with FK409 (n = 5); HA, hyaluronic acid; LA, group tested with L-arginine (n = 5); LDH, lactate dehydrogenase; TBA, total bile acid.

p < 0.05 versus group CT. Data are expressed as mean ± SEM.