Table 3.

Comparison of day 0 vs. day 28 concentrations of urinary biomarkers of interest for pre- and post-menopausal women consuming the treatment or a placebo.

Biomarker		Pre- and post-menopausal women n = 68
ng/mg creatinine		Treatment n = 38			Placebo n = 30
		Day 0	Day 28	P-value	Day 0	Day 28	P-value
2-OHE 1 + 2	Mean	7.63	15.11	0.001	9.77	11.13	0.524
	SD1	8.31	17.50		11.5	9.64
16α-OHE	Mean	5.46	6.50	0.082	6.05	5.66	0.620
	SD	4.50	5.07		4.76	3.93
2:16α-OHE ratio	Mean	2.52	3.33	0.074	2.17	2.70	0.451
	SD	3.70	3.78		2.95	3.46

¹Abbreviation: SD, standard deviation.