Table 2.
DEGs in original and recurrent meningiomas mapping at frequent significant chromosomal locations
| Gene symbol | Gene description | R vs O* | R** | O** |
|---|---|---|---|---|
| 1p | ||||
| PPAP2B | Phosphatidic acid phosphatase type 2B | −3.6 | −3.3 | −1.4 |
| LMO4 | LIM domain only 4 | −3.6 | n | 1.8 |
| CYR61 | Cysteine-rich, angiogenic inducer, 61 | −3.0 | −1.8 | n |
| EXTL2 | Exostoses (multiple)-like 2 | −2.5 | n | 0.9 |
| F3 | Coagulation factor III | −2.5 | −0.8 | 0.6 |
| DDAH1 | Dimethylarginine dimethylaminohydrolase 1 | −2.5 | −1.4 | n |
| PGM1 | Phosphoglucomutase 1 | −2.4 | −0.8 | n |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | −2.4 | −1.3 | n |
| DHRS3 | Dehydrogenase/reductase member 3 | −2.3 | −1 | n |
| BCAR3 | Breast cancer antiestrogen resistance 3 | −2.3 | −1.3 | n |
| TMEM50A | Transmembrane protein 50A | −2.3 | −1.7 | n |
| TGFBR3 | Transforming growth factor, β receptor III | −2.1 | −1.9 | −0.8 |
| PNRC2 | Proline-rich nuclear receptor coactivator 2 | −2.1 | −1.2 | n |
| CMPK | Cytidylate kinase | −2.0 | −1.4 | n |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | −2.0 | −1.2 | n |
| DPYD | Dihydropyrimidine dehydrogenase | −2.0 | −1.7 | −0.7 |
| MAN1C1 | Mannosidase, alpha, class 1C, member 1 | −2.0 | −0.8 | n |
| LPHN2 | Latrophilin 2 | −1.9 | −1.5 | n |
| SFRS4 | Splicing factor, arginine/serine-rich 4 | −1.9 | −1.8 | −0.8 |
| RPS8 | Ribosomal protein S8 | −1.9 | −1.2 | n |
| IPP | Intracisternal A particle-promoted polypeptide | −1.8 | n | 0.6 |
| HMGN2 | High-mobility group nucleosomal binding domain 2 | −1.8 | −1.7 | −0.9 |
| GSTM1 | Glutathione S-transferase M1 | −1.8 | n | 0.6 |
| GADD45A | Growth arrest and DNA-damage-inducible, alpha | −1.8 | −1.3 | n |
| CYP4X1 | Cytochrome P450, family 4, subfamily X, polypeptide 1 | 2.4 | 0.8 | 2.1 |
| 6p | ||||
| HIST1H1C | Histone cluster 1, H1c | 5.1 | 2.1 | n |
| PRPH2 | Peripherin 2 | 3.2 | n | 1.7 |
| HIST1H1E | Histone cluster 1, H1e | 3.0 | 1.2 | n |
| HIST1H1D | Histone cluster 1, H1d | 2.5 | 1.5 | n |
| HIST1H2AD | Histone cluster 1, H2ad | 2.2 | n | −1 |
| HIST1H2BH | Histone cluster 1, H2bh | 2.2 | 1.1 | n |
| HIST1H2BO | Histone cluster 1, H2bo | 2.1 | 1.1 | n |
| HIST1H2BN | Histone cluster 1, H2bn | 2.0 | 1 | n |
| HIST1H2BF | Histone cluster 1, H2bf | 2.0 | 1 | n |
| HIST1H2AE | Histone cluster 1, H2ae | 2.0 | n | −0.6 |
| HIST1H2BI | Histone cluster 1, H2bi | 2.0 | 0.9 | n |
| HIST1H2BL | Histone cluster 1, H2bl | 2.0 | 1 | n |
| HIST1H2BC | Histone cluster 1, H2bc | 1.9 | 1.3 | n |
| HIST1H2BE | Histone cluster 1, H2be | 1.9 | 0.8 | n |
| HIST1H2BG | Histone cluster 1, H2bg | 1.8 | 1.2 | n |
| HIST1H2BD | Histone cluster 1, H2bd | 1.8 | 1.5 | 0.7 |
| HIST1H2BM | Histone cluster 1, H2bm | 1.8 | 1 | n |
| GMDS | GDP-mannose 4,6-dehydratase | −1.9 | n | 0.9 |
| RAB23 | RAB23, member RAS oncogene family | −2.2 | n | 0.9 |
| HSPA1A | Heat shock 70 kDa protein 1A | −2.8 | −1 | n |
| 6q | ||||
| CTGF | Connective tissue growth factor | −5.5 | −2.3 | n |
| PRSS35 | Protease, serine, 35 | −3.6 | n | 1.8 |
| MAP3K5 | Mitogen-activated protein kinase 5 | −2.6 | −2.4 | −1.1 |
| RNF146 | Ring finger protein 146 | −2.4 | −1.5 | n |
| EPB41L2 | Erythrocyte membrane protein band 4.1-like 2 | −2.3 | −1.1 | n |
| PNRC1 | Proline-rich nuclear receptor coactivator 1 | −2.2 | −1.2 | n |
| SERINC1 | Serine incorporator 1 | −2.2 | −1.7 | −0.6 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | −2.1 | −1.5 | n |
| SESN1 | Sestrin 1 | −2.1 | −1.5 | n |
| CNKSR3 | CNKSR family member 3 | −1.9 | −0.6 | n |
| SNX3 | Sorting nexin 3 | −1.9 | −1.7 | −0.7 |
| TSPYL4 | TSPY-like 4 | −1.9 | −1.1 | n |
| FOXO3A | Forkhead box O3A | −1.9 | n | 0.6 |
| CD164 | CD164 molecule, sialomucin | −1.9 | −0.9 | n |
| DLL1 | Delta-like 1 | −1.8 | −2.3 | −1.5 |
| ME1 | Malic enzyme 1, NADP(+)-dependent, cytosolic | −1.8 | n | 0.6 |
| CCDC28A | Coiled-coil domain containing 28A | −1.8 | −0.7 | n |
| 14q | ||||
| TMEM30B | Transmembrane protein 30B | −5.8 | −2.3 | n |
| SMOC1 | SPARC-related modular calcium binding 1 | −3.0 | −0.6 | 1 |
| LTBP2 | Latent transforming growth factor β binding protein 2 | −2.9 | −1.6 | n |
| KLHDC2 | Kelch domain containing 2 | −2.1 | −0.8 | n |
| SIPA1L1 | Signal-induced proliferation-associated 1 like 1 | −1.9 | −0.8 | n |
| PRKCH | Protein kinase C, eta | −1.8 | −1.9 | −1 |
| TRMT5 | TRM5 tRNA methyltransferase 5 homolog | −1.8 | −1.6 | −0.8 |
| ALDH6A1 | Aldehyde dehydrogenase 6 family, member A1 | 2.2 | n | 1.2 |
Negative and positive values indicate the lower and the higher levels of expression, respectively, in recurrences vs original tumors, recurrences vs nontumoral tissue, or original tumors vs nontumoral tissue. n, expression data similar to that of nontumoral tissue.
*Differences of expression between recurrent (R) and original (O) tumors.
**Log2 mean expression values of recurrent (R) and original (O) meningiomas normalized to nontumoral meningothelial tissues.