Table 2.
Patients characteristics, site, and type of relapse with regard to the radiation RT field
| Patient number | Primary site | Margins of radiation (technique) | Delay of relapse (months) | Type of relapse | Site of relapse/RT field | Treatment at first relapse | Treatment at second relapse | Outcome (follow-up from first relapse) |
|---|---|---|---|---|---|---|---|---|
| 1 | Suprasellar | 2 cm (2 fields) | 121 | Optic nerve meningeal sheath | Marginal | C-HDC | C | DOD (43) |
| 2 | Bifocal | 2 cm (2 fields) | 29 | Periventricular (frontal horns) | Marginal | C-HDC-RT | alive (54+) | |
| 3 | Pineal | 0.3–1.2 cm (4 fields) | 31 | Periventricular (peribulbar) | Marginal | C-HDC-CSI | alive (57+) | |
| 4 | Pineal | 1.5–2.5 cm (4 fields) | 57 | Periventricular (occipital horns) and leptomeningeal (infratentorial) | Marginal and out- field proximal | –C-HDC-S | C-CSI | alive (98+) |
| 5 | Pineal | 1–3 cm (4 fields) | 10 | Periventricular (left and right ventricles) | In-field and out-field proximal | C-HDC | alive (130+) | |
| 6 | Pineal | 0.7 cm (arc therapy) | 21 | Primary site and periventricular (frontal and temporal horns) | In-field and out-field proximal | C-HDC | C-S-CSI | alive (87+) |
| 7 | Pineal | 1–2.5 cm (4 fields) | 10 | Leptomeningeal spinal (C5, C7, T12) + CSF | Distant | –C-RT | C | DOD (20) |
| 8 | Pineal | 0.5–2 cm (2 fields) | 38 | Primary site, pituitary stalk, chiasm, and Periventricular nodules + CSF | In-field and out-field proximal | C-CSI | alive (177+) | |
| 9 | Suprasellar | 2 cm (4 fields) | 59 | Periventricular (frontal horn + third ventricle) | In-field and marginal | C-HDC | alive (54+) | |
| 10 | Suprasellar | >2 cm (4 fields) | 33 | Periventricular (frontal horns) | In-field and marginal | C-HDC | C-CSI | alive (94+) |
Abbreviations: C, chemotherapy; HDC, high-dose chemotherapy; S, surgery; RT, radiotherapy; CSI, craniospinal irradiation; DOD, dead of disease.