Table 1.

Kinin-forming activity and endogenous bradykinin level in organs and fluids of TK^+/− and TK^−/− mice as compared with TK^+/+ mice

Strain	Kinin-forming activity							Endogenous bradykinin
	pg of BK/h per μg of protein					ng of BK/min per 24-h excretion		fmol/g of tissue
	Kidneys, n = 7	Colon, n = 7	Pancreas, n = 15	Salivary glands, n = 7	Heart, n = 7	Urine, n = 6	Feces, n = 14	Kidneys, n = 16	Heart, n = 16
+/+	32.6  ± 6.1	32.7  ± 11.5	5,077  ± 1,364	518,743  ± 114,978	1.6  ± 1.1	2,384  ± 164	1,708  ± 452	9.2  ± 1.4	<X
+/−	12.3  ± 2.4	11.6  ± 5.3	1,846  ± 805	118,800  ± 19,697	0.8  ± 0.6	887  ± 173	958  ± 334	NM	NM
−/−	1.2  ± 0.4	1.8  ± 1.0	14  ± 2	7,629  ± 1,856	1.2  ± 0.4	10  ± 1	17  ± 2	2.1  ± 0.5	<X
P	0.0001	0.02	0.0008	0.0001	0.56	0.0001	0.002	0.0001	NA

The detection limit X of endogenous bradykinin (BK) was 1.3 fmol/g of tissue. Values (means ± SEM) have been compared by ANOVA. NM, not measured; NA, not applicable.