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Proliferative activity assessed with the Ki-67 antibody. Ki-67 immunoreactivity is broadly distributed throughout the dysplastic epithelium at the top of the crypts (A and B). Within the normal-appearing epithelium at the bottom of the crypts, only the basal and surrounding cell layers are labeled (A and B), similar to the pattern observed in normal colonic epithelium unassociated with neoplasia (C).
