Table 1.

Summary of LOH and mutations of APC in adenomas

Specimen no.	Location	In APC	Mutation
1	Superficial adenomatous	LOH	1356 Ser → Stop
	Underlying “normal”	R	wt
2	Superficial adenomatous	LOH	ND
	Underlying “normal”	R	ND
3	Superficial adenomatous	LOH	FS (8-bp del at 1487)
	Underlying “normal”	R	wt
4	Superficial adenomatous	LOH	FS (5-bp del at 1309)
	Underlying “normal”	R	wt
5	Superficial adenomatous	LOH	1378 Gln → Stop
	Underlying “normal”	R	wt
6	Superficial adenomatous	R	wt
	Underlying “normal”	R	ND
7	Superficial adenomatous	R	1450 Arg → Stop
	Underlying “normal”	R	wt
8	Superficial adenomatous	R	1367 Gln → Stop
	Underlying “normal”	R	wt
9	Superficial adenomatous	R	FS (2-bp del at 1399)
	Underlying “normal”	R	ND
10	Superficial adenomatous	R	wt
	Underlying “normal”	R	ND

R, retained both alleles; wt, wild type; ND, not done (insufficient DNA); FS, frame shift; del, deletion of nucleotides.