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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Cytoskeleton (Hoboken). 2010 Nov 10;67(12):808–823. doi: 10.1002/cm.20490

Figure 8.

Figure 8

(A-E) Representative images of myofibrils in cardiomyocytes transfected with the C-terminal three SH3 domains of ArgBP2 (Arg-21). (A-C) The SH3 domains (A, green in C) target to the prominent Z-bands and to Z-bodies along the right side of the cell. Evidence of some myofibril disruption is seen in the round aggregates in the YFP image in (A) and in the green balls in (C). Alpha-actinin antibody staining (B, red in merged image in C) is colocalized with the ArgBP2 fragment except in the round aggregates. (D, E) Higher levels of expression cause disruption of myofibrils and formation of more round aggregates. Alpha-actinin antibody staining colocalizes with the disassembling myofibrils, but not with the round aggregates (D). Bars = 10 microns.