Table 2.

Prevalence of Retinal Angiomatosis by VHL Mutational Class

Type of Mutational Class	Presence of Retinal Angiomatosis (in at least one eye)
	Yes	No	Total	Prevalence of Retinal Angiomatosis*
Amino-acid Substitution	159	259	418	38.0%
Protein Truncation	142	212	354	40.1%
Complete Deletion	9	53	62	14.5%**
Total	310	524	834	37.1%

Comparison	Odds ratio (95% confidence limits) for rate of RCH present vs. RCH absent **	P value
Amino-acid substitution vs. Protein Truncation	1.01(0.67-1.54)	0.9453
Amino-acid substitution vs. Complete deletion	5.85 (2.51-13.65)	<.0001
Protein Truncation vs. Complete deletion	5.77 (2.45-13.59)	<.0001

^*Calculated as number of patients with retinal angiomatosis divided by total number of patients in each subset.

^**Analyses were adjusted for age, gender, and familial relationships.