Table 2. The constitutive expression of humoral immunity genes is altered in spaceflight larvae.
| Gene Category | Symbol | Probe # | Adjusted p-value | Up or Down | Fold Change |
| AMP response | |||||
| immune deficiency | imd | 1637332 | 1.3×10−2 | D | 0.80 |
| spatzle | spz | 1641068 | 1.3×10−2 | D | 0.72 |
| Spatzle-processing enzyme | SPE | 1634848 | 4.7×10−3 | U | 1.49 |
| spheroide | spheroide | 1624578 | 2.8×10−3 | U | 1.90 |
| Ect4 | Ect4 | 1632067 | 2.7×10−2 | U | 1.44 |
| Calpain-A | CalpA | 1628628 | 1.9×10−3 | U | 1.49 |
| dorsal | dl | 1623415 | 2.1×10−4 | D | 0.60 |
| Metchnikowin | Mtk | 1627613 | 3.9×10−7 | D | 0.16 |
| Attacin-D | AttD | 1631475 | 8.7×10−7 | D | 0.42 |
| Attacin-C | AttC | 1641419 | 6.2×10−5 | D | 0.24 |
| Drosomycin | Drs | 1635189 | 3.5×10−4 | D | 0.57 |
| Attacin-A | AttA | 1625124 | 5.4×10−4 | D | 0.14 |
| Drosocin | Dro | 1631697 | 6.6×10−3 | D | 0.70 |
| Other humoral factors | |||||
| Thor | Thor | 1635900 | 8.5×10−3 | D | 0.78 |
| Stress factors | |||||
| Turandot A | TotA | 1635549 | 8.7×10−7 | D | 0.12 |
| Turandot C | TotC | 1639323 | 4.3×10−4 | D | 0.36 |
| Bacterial cell wall lysis | |||||
| Lysozyme X | LysX | 1632720 | 4.6×10−11 | D | 0.14 |
| Lysozyme P | LysP | 1636767 | 7.3×10−4 | D | 0.52 |
| Melanization | |||||
| Black cells | Bc | 1635494 | 3.2×10−11 | D | 0.29 |
Specific classes of genes involved in the humoral immune response that were altered by spaceflight included: the AMP response pathway, the stress factors turandot A and C, the lysozyme genes and the melanization gene black cells. Although some of the genes upstream of AMPs were upregulated, the target AMP effectors were all downregulated. The statistical significance of gene changes is shown by the adjusted p-value at an FDR threshold of less than 0.05.