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In vitro NAMPT enzyme assays. A: kcat values for wild type NAMPT (NAMPTwt) and NAMPT with K342R, H191R and D93del mutations respectively. Statistical significance compared with NAMPTwt: **: <0.0005, ***: <0.0001. B: IC50 values of APO866 for in vitro inhibition of NAMPTwt and NAMPTH191R. The Y-axis is logarithmic. Statistical significance compared with NAMPTwt: *: <0,05. Error bars indicate SEM.
