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. 2011 Jan 11;6(1):e16090. doi: 10.1371/journal.pone.0016090

Figure 3. Tl1a Tg mice do not develop gross intestinal inflammation but exhibit enhanced colonic fibrosis.

Figure 3

(A) Gross appearance (wall thickening, hyperemia, rigidity or adhesions) of small intestine and colon are measured from 10 months old WT, LCK-CD2-Tl1a Tg (L-Tg) or FMS-Tl1a Tg (M-Tg) mice using a standard scoring system [21]. Data are expressed as mean ± SD. (B) Myeloperoxidase (MPO) activity is measured on the distal 3 cm of ilea and mid-colon and data are expressed as arbitrary unit (U) per gram (g) of protein. *P<0.05 (C) Representative hematoxylin and eosin (H&E) stained colon section obtained from mid-colon of 10 months old WT, LCK-CD2-Tl1a Tg or FMS-Tl1a Tg mice are shown. (D) Masson Trichrome staining of collagen deposition in tissue sections of mouse mid-colon. Collagen is stained blue versus red background. There are increased blue collagen stain in LCK-CD2-Tl1a Tg and FMS-Tl1a Tg compared to WT littermate mice. Magnification 200X. Results are representative of six mice per group for A–D.